On the Week 4 NFL schedule, we have the Chargers (+8) as the best bet on the card. See below for more tips on point spreads and over/unders, including parlay possibilities.

Take advantage of our predictions to make your NFL picks this week. BetMGM has all the information you need to begin betting on the NFL.

Best Week 4 Spread Bets

Jump to Matchup:

CLE-LV | NO-ATL | TEN-MIA | PIT-IND | PHI-TB

Pick: Raiders -1 vs. Browns

• Matchup: Cleveland Browns at Las Vegas Raiders
• Projected Winner & Margin: Raiders by 6.3 points (Bet on this game at BetMGM)
• Spread: Raiders -1
• Time: 4:25 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Saints +1.5 vs. Falcons

• Matchup: New Orleans Saints at Atlanta Falcons
• Projected Winner & Margin: Saints by 0.4 points (Bet on this game at BetMGM)
• Spread: Falcons -1.5
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Dolphins +1.5 vs. Titans

• Matchup: Tennessee Titans at Miami Dolphins
• Projected Winner & Margin: Dolphins by 5.0 points (Bet on this game at BetMGM)
• Spread: Titans -1.5
• Time: 7:30 PM ET
• Date: Sept. 30
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Steelers -2 vs. Colts

• Matchup: Pittsburgh Steelers at Indianapolis Colts
• Projected Winner & Margin: Steelers by 4.5 points (Bet on this game at BetMGM)
• Spread: Steelers -2
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Buccaneers +2.5 vs. Eagles

• Matchup: Philadelphia Eagles at Tampa Bay Buccaneers
• Projected Winner & Margin: Buccaneers by 2.5 points (Bet on this game at BetMGM)
• Spread: Eagles -2.5
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 4 Total Bets

Jump to Matchup:

Over 46.5 – Bills vs. Ravens

• Matchup: Buffalo Bills at Baltimore Ravens
• Projected Total: 51.5 points (Bet on this game at BetMGM)
• Time: 8:20 PM ET
• Date: Sept. 29
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 39 – Chiefs vs. Chargers

• Matchup: Kansas City Chiefs at Los Angeles Chargers
• Projected Total: 38.0 points (Bet on this game at BetMGM)
• Time: 4:25 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Under 43.5 – Vikings vs. Packers

• Matchup: Minnesota Vikings at Green Bay Packers
• Projected Total: 41.3 points (Bet on this game at BetMGM)
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Over 42.5 – Saints vs. Falcons

• Matchup: New Orleans Saints at Atlanta Falcons
• Projected Total: 42.8 points (Bet on this game at BetMGM)
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 40 – Steelers vs. Colts

• Matchup: Pittsburgh Steelers at Indianapolis Colts
• Projected Total: 32.7 points (Bet on this game at BetMGM)
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Catch every NFL touchdown with NFL RedZone on Fubo.

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