MLB Betting Lines and Picks Today | Sept. 22

Published 9:22 pm Saturday, September 21, 2024

In a Sunday MLB slate that has a lot of compelling contests, the Arizona Diamondbacks versus the Milwaukee Brewers is a game to watch.

Trying to gain an edge in the MLB? We break down the betting odds for all the important matchups on Sunday below.

Email newsletter signup

Place your bets on any MLB matchup at BetMGM. Sign up today using our link.

MLB Betting Info Today – Sept. 22

Minnesota Twins (81-73) at Boston Red Sox (76-78)

Betting Info & Picks

  • Moneyline Favorite: Red Sox
  • Moneyline Underdog: Twins
  • Total: Runs ( to go over, to go under)
  • Prediction: Red Sox 5, Twins 4
  • Moneyline Pick: Red Sox () over the Twins ()

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: BSN
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 12:35 PM ET
  • Venue: Fenway Park
  • Location: Boston, Massachusetts
  • Red Sox Starter: Nick Pivetta (5-11, 4.37 ERA)
  • Twins Starter: Zebby Matthews (1-3, 6.3 ERA)

Pittsburgh Pirates (72-83) at Cincinnati Reds (76-80)

Betting Info & Picks

  • Moneyline Favorite: Reds -120
  • Moneyline Underdog: Pirates +100
  • Total: 8 Runs (-110 to go over, -110 to go under)
  • Prediction: Reds 5, Pirates 4
  • Moneyline Pick: Reds (100) over the Pirates (-120)
  • Total Pick: Over 8 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: SportsNet PT
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 1:10 PM ET
  • Venue: Great American Ball Park
  • Location: Cincinnati, Ohio
  • Reds Starter: Hunter Greene (9-4, 2.83 ERA)
  • Pirates Starter: Paul Skenes (10-3, 2.07 ERA)

Get tickets for any MLB game this season at StubHub.

Detroit Tigers (81-74) at Baltimore Orioles (86-69)

Betting Info & Picks

  • Moneyline Favorite: Orioles
  • Moneyline Underdog: Tigers
  • Total: Runs ( to go over, to go under)
  • Prediction: Orioles 5, Tigers 4
  • Moneyline Pick: Orioles () over the Tigers ()

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: MASN
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 1:35 PM ET
  • Venue: Oriole Park at Camden Yards
  • Location: Baltimore, Maryland
  • Orioles Starter: Albert Suarez (8-6, 3.6 ERA)
  • Tigers Starter: Casey Mize (2-6, 4.36 ERA)

Toronto Blue Jays (73-82) at Tampa Bay Rays (77-78)

Betting Info & Picks

  • Moneyline Favorite: Rays
  • Moneyline Underdog: Blue Jays
  • Total: Runs ( to go over, to go under)
  • Prediction: Rays 4, Blue Jays 3
  • Moneyline Pick: Rays () over the Blue Jays ()

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: BSSUN
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 1:40 PM ET
  • Venue: Tropicana Field
  • Location: St. Petersburg, Florida
  • Rays Starter: Shane Baz (3-3, 3.21 ERA)
  • Blue Jays Starter: Chris Bassitt (10-13, 4.16 ERA)

Atlanta Braves (84-71) at Miami Marlins (57-98)

Betting Info & Picks

  • Moneyline Favorite: Braves -200
  • Moneyline Underdog: Marlins +165
  • Total: 9 Runs (+100 to go over, -120 to go under)
  • Prediction: Braves 6, Marlins 5
  • Moneyline Pick: Braves (-200) over the Marlins (+165)
  • Total Pick: Over 9 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: MLB Network
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 1:40 PM ET
  • Venue: LoanDepot park
  • Location: Miami, Florida
  • Marlins Starter: Darren McCaughan (0-0, 7.64 ERA)
  • Braves Starter: Grant Holmes (2-1, 3.84 ERA)

Watch MLB on Fubo and Apple TV+

Los Angeles Angels (62-92) at Houston Astros (84-70)

Betting Info & Picks

  • Moneyline Favorite: Astros -275
  • Moneyline Underdog: Angels +220
  • Total: 8.5 Runs (-110 to go over, -110 to go under)
  • Prediction: Astros 5, Angels 4
  • Moneyline Pick: Astros (-275) over the Angels (+220)
  • Total Pick: Over 8.5 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: BSW
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 2:10 PM ET
  • Venue: Minute Maid Park
  • Location: Houston, Texas
  • Astros Starter: Spencer Arrighetti (7-13, 4.68 ERA)
  • Angels Starter: Griffin Canning (6-13, 5.21 ERA)

San Francisco Giants (76-79) at Kansas City Royals (82-73)

Betting Info & Picks

  • Moneyline Favorite: Royals -115
  • Moneyline Underdog: Giants -105
  • Total: 7.5 Runs (+100 to go over, -120 to go under)
  • Prediction: Royals 5, Giants 4
  • Moneyline Pick: Royals (-105) over the Giants (-115)
  • Total Pick: Over 7.5 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: BSKC
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 2:10 PM ET
  • Venue: Kauffman Stadium
  • Location: Kansas City, Missouri
  • Royals Starter: Seth Lugo (16-8, 3.05 ERA)
  • Giants Starter: Blake Snell (4-3, 3.31 ERA)

Arizona Diamondbacks (86-68) at Milwaukee Brewers (88-66)

Betting Info & Picks

  • Moneyline Favorite: Brewers -120
  • Moneyline Underdog: Diamondbacks +100
  • Total: 8.5 Runs (-115 to go over, -105 to go under)
  • Prediction: Brewers 5, Diamondbacks 4
  • Moneyline Pick: Brewers (-120) over the Diamondbacks (+100)
  • Total Pick: Over 8.5 Runs

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: BSWI
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 2:10 PM ET
  • Venue: American Family Field
  • Location: Milwaukee, Wisconsin
  • Brewers Starter: Frankie Montás (7-11, 4.5 ERA)
  • Diamondbacks Starter: Jordan Montgomery (8-7, 6.23 ERA)

Cleveland Guardians (90-65) at St. Louis Cardinals (77-77)

Betting Info & Picks

  • Moneyline Favorite: Cardinals
  • Moneyline Underdog: Guardians
  • Total: Runs ( to go over, to go under)
  • Prediction: Cardinals 5, Guardians 4
  • Moneyline Pick: Cardinals () over the Guardians ()

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: BSGL
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 2:15 PM ET
  • Venue: Busch Stadium
  • Location: St. Louis, Missouri
  • Cardinals Starter: Andre Pallante (7-8, 3.87 ERA)
  • Guardians Starter: Gavin Williams (3-10, 5.12 ERA)

Washington Nationals (69-86) at Chicago Cubs (79-76)

Betting Info & Picks

  • Moneyline Favorite: Cubs
  • Moneyline Underdog: Nationals
  • Total: Runs ( to go over, to go under)
  • Prediction: Cubs 4, Nationals 3
  • Moneyline Pick: Cubs () over the Nationals ()

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: MARQ
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 2:20 PM ET
  • Venue: Wrigley Field
  • Location: Chicago, Illinois
  • Cubs Starter: Shota Imanaga (14-3, 3.03 ERA)
  • Nationals Starter: Jake Irvin (10-12, 4.07 ERA)

Seattle Mariners (79-75) at Texas Rangers (73-81)

Betting Info & Picks

  • Moneyline Favorite: Mariners
  • Moneyline Underdog: Rangers
  • Total: Runs ( to go over, to go under)
  • Prediction: Mariners 5, Rangers 4
  • Moneyline Pick: Mariners () over the Rangers ()

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: BSSW
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 2:35 PM ET
  • Venue: Globe Life Field
  • Location: Arlington, Texas
  • Rangers Starter: Andrew Heaney (5-14, 3.89 ERA)
  • Mariners Starter: Bryan Woo (8-3, 2.85 ERA)

New York Yankees (90-64) at Oakland Athletics (67-87)

Betting Info & Picks

  • Moneyline Favorite: Yankees
  • Moneyline Underdog: Athletics
  • Total: Runs ( to go over, to go under)
  • Prediction: Yankees 6, Athletics 5
  • Moneyline Pick: Yankees () over the Athletics ()

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: NBCS-CA
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 4:07 PM ET
  • Venue: Oakland-Alameda County Coliseum
  • Location: Oakland, California
  • Athletics Starter: Joey Estes (7-8, 4.78 ERA)
  • Yankees Starter: Luis Gil (14-6, 3.14 ERA)

Colorado Rockies (59-95) at Los Angeles Dodgers (92-62)

Betting Info & Picks

  • Moneyline Favorite: Dodgers
  • Moneyline Underdog: Rockies
  • Total: Runs ( to go over, to go under)
  • Prediction: Dodgers 5, Rockies 3
  • Moneyline Pick: Dodgers () over the Rockies ()

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: COLR
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 4:10 PM ET
  • Venue: Dodger Stadium
  • Location: Los Angeles, California
  • Dodgers Starter: Yoshinobu Yamamoto (6-2, 2.63 ERA)
  • Rockies Starter: Antonio Senzatela (0-0, 6 ERA)

Chicago White Sox (36-118) at San Diego Padres (88-66)

Betting Info & Picks

  • Moneyline Favorite: Padres
  • Moneyline Underdog: White Sox
  • Total: Runs ( to go over, to go under)
  • Prediction: Padres 5, White Sox 3
  • Moneyline Pick: Padres () over the White Sox ()

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: SDPA
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 4:10 PM ET
  • Venue: PETCO Park
  • Location: San Diego, California
  • Padres Starter: Yu Darvish (6-3, 3.21 ERA)
  • White Sox Starter: Sean Burke (1-0, 2.25 ERA)

Minnesota Twins (81-73) at Boston Red Sox (76-78)

Betting Info & Picks

  • Moneyline Favorite: Red Sox
  • Moneyline Underdog: Twins
  • Total: Runs ( to go over, to go under)
  • Prediction: Red Sox 6, Twins 5
  • Moneyline Pick: Red Sox () over the Twins ()

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: BSN
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 5:35 PM ET
  • Venue: Fenway Park
  • Location: Boston, Massachusetts
  • Red Sox Starter: Kutter Crawford (8-15, 4.19 ERA)
  • Twins Starter: Pablo Lopez (15-8, 3.84 ERA)

Philadelphia Phillies (92-63) at New York Mets (86-69)

Betting Info & Picks

  • Moneyline Favorite: Mets
  • Moneyline Underdog: Phillies
  • Total: Runs ( to go over, to go under)
  • Prediction: Mets 5, Phillies 4
  • Moneyline Pick: Mets () over the Phillies ()

Bet on this or any MLB matchup at BetMGM.

How to Watch

  • TV Channel: ESPN
  • Live Stream: Watch on Fubo (Regional restrictions may apply)
  • Game Time: 7:15 PM ET
  • Venue: Citi Field
  • Location: Queens, New York
  • Mets Starter: Tylor Megill (4-5, 4.08 ERA)
  • Phillies Starter: Zack Wheeler (16-6, 2.56 ERA)

Catch MLB action all season long on Fubo.

id: