Saturday’s game between the No. 25 Louisville Cardinals (20-6, 13-2 ACC) and the Florida State Seminoles (16-10, 7-8 ACC) at KFC Yum! Center is expected to be a one-sided matchup, as our computer prediction projects a final score of 80-68 and heavily favors Louisville to take home the win. Game time is at 12:00 PM ET on February 22.

Based on our computer prediction, Florida State is a good bet to cover the point spread, which is listed at 13.5. The two sides are projected to go under the 151.5 total.

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Louisville vs. Florida State Game Info & Odds

• Date: Saturday, February 22, 2025
• Time: 12:00 PM ET
• TV: The CW
• Live stream: Watch this game on Fubo (Regional restrictions may apply)
• Where: Louisville, Kentucky
• Venue: KFC Yum! Center
• Line: Louisville -13.5
• Point total: 151.5
• Moneyline (to win): Louisville -1250, Florida State +740

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Louisville vs. Florida State Score Prediction

• Prediction:
  Louisville 80, Florida State 68

Spread & Total Prediction for Louisville vs. Florida State

• Pick ATS: Florida State (+13.5)
• Pick OU: Under (151.5)

Louisville’s record against the spread this season is 16-10-0, while Florida State’s is 14-12-0. In terms of going over the point total, games involving the Cardinals are 9-17-0 and the Seminoles are 11-15-0. The two teams combine to score 154.8 points per game, 3.3 more points than this matchup’s total. Louisville is 7-3 against the spread and 9-1 overall in its last 10 contests, while Florida State has gone 4-6 against the spread and 5-5 overall.

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Louisville Performance Insights

• The Cardinals are outscoring opponents by 10.5 points per game with a +274 scoring differential overall. They put up 79.5 points per game (54th in college basketball) and allow 69.0 per contest (94th in college basketball).
• Louisville records 35.7 rebounds per game (27th in college basketball) while conceding 29.7 per contest to its opponents. It outrebounds opponents by 6.0 boards per game.
• Louisville makes 10.0 three-pointers per game (26th in college basketball), 2.3 more than its opponents (7.7). It is shooting 32.8% from deep (244th in college basketball) while allowing opponents to shoot 34.2%.
• The Cardinals score 101.7 points per 100 possessions (48th in college basketball), while allowing 88.2 points per 100 possessions (67th in college basketball).
• Louisville has won the turnover battle on average this season, committing 10.8 per game (132nd in college basketball action) while forcing 12.5 (91st in college basketball).

Florida State Performance Insights

• The Seminoles outscore opponents by 4.6 points per game (posting 75.3 points per game, 141st in college basketball, and giving up 70.7 per outing, 145th in college basketball) and have a +118 scoring differential.
• Florida State records 32.0 rebounds per game (180th in college basketball), compared to the 31.6 of its opponents.
• Florida State hits 1.7 fewer threes per game than the opposition, 6.2 (327th in college basketball) compared to its opponents’ 7.9.
• Florida State has committed 1.4 fewer turnovers than its opponents, averaging 12.4 (282nd in college basketball) while forcing 13.8 (34th in college basketball).

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